Genetic regulation of myogenesis:
The goal of this project is to characterize the transcriptional network governed by key transcriptional regulators that regulates satellite cell function in normal and dystrophin deficient skeletal muscle.
Satellite stem cells from skeletal muscle for the treatment of neuromuscular disease:
The goal of this project is to identify and characterize a subset of muscle satellite cells that function as the stem cell of the satellite cell compartment.
Molecular regulation of satellite cell function:
The major goals of this project are to investigate the function of satellite stem cells and Wnt signaling in mouse models of Duchenne Muscular Dystrophy.
Genetic regulation of skeletal muscle repair:
The goal of this project is to investigate the molecular regulation of Pax7 in satellite stem cells during asymmetric stem cell divisions.
Novel therapeutics for regenerative medicine:
We are developing therapeutics for the treatment of muscle wasting and other diseases.